THE POTENTIAL THERAPEUTIC VALUE OF GREEN TEA AND THYME AQUEOUS EXTRACTS ON IMIDACLOPRID TOXICITY IN RATS
Hesham S. El-Sabbagh, Omaima A. Khamiss, Nermeen B. El-Borai* and Basma A. El-Khadrawey
ABSTRACT
Imidacloprid (IMI) is the most extensively used neonicotinoid causing many adverse health effects. The use of natural antioxidants as an alternative medicine may play a crucial role to minimize the harmful effects of insecticides. Therefore, the present study was designed to evaluate the probable ameliorative effect of green tea aqueous extract (GAE) or thyme aqueous extract (TAE) against geno-oxidative and pathological disorders induced by IMI administered at 450 ppm in the diet for 3 months to rats. Intoxicated rats exhibited significant increase in serum ALT and AST activities. Significant increase of MDA level with significant reduction in GSH content and CAT activity in liver and brain were also recorded. Moreover, IMI induced DNA damage and several pathological alterations in liver and brain tissues. On the other hand, the concurrent exposure of rats to GAE or TAE alleviated all the toxic effects evoked by IMI. In conclusion, GAE and TAE may provide a promising therapeutic value against IMI and other neonicotinoid toxic insults.
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