Abstract

Dr. Muthumari M.* and Manoharan A.

ABSTRACT

The Vellarugu Chooranam (VC) (Enicostemma axillare (Lam.) is one of the important drug in Siddha system, because it was used various formed in the system. The aim of the study was to evaluate the analgesic and anti-inflammatory activities of Vellarugu chooranam (Enicostemma axillare Linn) in male albino rat models (180 ± 5 g). The analgesic activity of Vellarugu chooranam was assessed by acetic-acid writhing test. The Anti-inflammatory effect was analyzed by carrageenan induced paw edema and pleurisy induced methods. The analysis of experimental data was performed by statistical process of ANOVA to determine the variability of sample, while Newman-Keul's multiple range was performed for evaluation of comparative analgesic and anti-inflammatory activity of Vellarugu chooranam with control and standard. The writhing test showed a significant increase in the mean reaction time to stimuli in both 100 mg/kg and 200 mg/kg BW doses throughout the observation period in 30 minutes after treatment, which was comparable to the standard Diclofenac sodium and control group. In analgesic and anti-inflammatory studies showed, the inhibition of pain percentage and inflammation was noted. This result was Comparing with control and treatment groups. The results was 1.22 ±0.14, 1.42±0.19 and percentage in paw values is 65.73%, 60.11% respectively. The carragenan induced pleurisy in rat models showed decrease in pleural exudates and Leukocytes count was 0.24±0.13, 0.20±0.11 and 0.008±0.12, 0.50%±0.09% respectively.