Abstract

P. Khamrunisa Begam*, K. Manasa and K. Thirumala Naik

ABSTRACT

Muscle inflammation is a hallmark of the autoimmune illness myositis. Muscleinflammation is a common secondary symptom of lupus, scleroderma, andvasculitis patients, although the condition can manifest in many different ways. Itincludes the following types like polymyositis, dermatomyositis, juvenile myositis,ocular myositis, necrotizing myopathy, sporadic inclusion myositis and toxicmyositis. Accurate diagnosis of myositis requires a detailed medical history andphysical examination. A laboratory examination typically shows elevated CK, but itis also possible to find myositis-specific autoantibodies and other enzymesincluding LDH, AST, or ALT. Magnetic resonance imaging (MRI) can identifychanges in signal intensity inside the muscle.Since a biopsy is the only methodavailable to differentiate between the various myositis subtypes, it is both the mostcrucial and invasive step in making the right diagnosis. The pharmacologicaltreatment incudes glucocorticoids, adrenocorticotrophic gel, methothrexate,azathioprine, cyclophosphamide, hydroxy chloroquine, calcineurin inhibitors,mycophenolate mofetil, intravenous Immunoglobulins, biological and nonbiological products. The non pharmacological treatment includes interchange ofplasma and leukapheresis, exercises e.t.c.