Abstract

Dr. P. Bernath* and A. Manoharan

ABSTRACT

Background: Nerunji Ver Kudineer (NVK) is a siddha poly herbal formulation consisting of equal proportions of four ingredients. Siddha system of medicines possesses wide range of medicines with different sources of origin for treating various disease. Since a poly herbal formulation contains numerous bioactive principles it has ability to cure multiple clinical conditions. Aim and Objective: To determine the anti inflammatory action of Nerunji Ver Kudineer (NVK) by using Wistar Albino rats. Method: The concerned study was carried out by carrageenan induced paw edema method. Male adult albino wistar rats were selected and divided into 5 groups with each containing 5 rats. Beside negative control Group II-V were administered with carrageenan and produced paw edema. Group III (Indomethacin) was treated with standard medicine whereas Group IV and V where treated with NVK at dose of 100 mg/kg/bw and 200mg/kg/bw respectively. In order to measure the edema, linear paw circumference was measured using vernier caliper after 4 hours of carrageenan introduction. Similarly, carrageenan induced pleurisy was analysed. For this rat models were administered with carrageenan which caused pleurisy and treated with NVK at the dose of 100mg/kg/bw and 200mg/kg/BW. After 3 hours the rat models were sacrificed. Then total leucocyte count in exudates was calculated. Result: The siddha drug NVK showed marked reduction in paw edema and pleurisy in albino Wistar rat models. Conclusion: It can be concluded that NVK posses significant anti inflammatory activity in albino Wistar Rat Models.