Abstract

Yuvraj Vishwakarma*, Yuvraj Dangi, Ravish Sahu, Ajay Singh Thakur, Ramdarshan Parashar, Yogesh Sharma and Deepak Koshti

ABSTRACT

Sustained or controlled release of drug, genetic material and biologically activeingredient are achieved through nanoemulsion which is the novel drug deliverysystem. Nanoemulsion is an anisotropically clear and kinetically or thermodynamicallystable liquid solution, consisting of oil, surfactant and an aqueousphase, generally droplet diameter of 10-500 nm. Preparation of Etoposide andCurcumin containing lipidic nanoemulsion was proposed. Optimization offormulation was done using various oils, surfactant ratios and stabilizers. Twoformulations using vitamin E acetate as oil, tween 80 and labrasol as surfactant andphosphatidylcholine as stabilizer were prepared using ultrasonication method, byvarying volume ratio of vitamin E acetate 1% v/v and 2% v/v. These o/wnanoemulsions were prepared and checked for their particle size, zeta potential.Particle size obtained was 162.7 nm and 137.1 nm, and polydispercity indexobtained was 0.224 and 0.226 respectively, which showed uniform distribution ofglobules in the nanoemulsion. The Zeta Potential curve of optimized nanoemulsionimplies that the nanoemulsion were in the satiability region between -25 to -35 mV.The amount of released etoposide and curcumin gradually decreases with respect totime. In vitro drug release profile showed biphasic release behavior with an initialburst effect followed by slow and sustained release. This obviously results in alower release of drug from nanoemulsion. Thus it may be concluded thatnanoemulsion could be a better option for the parenteral (i.p.) delivery of etoposideand curcumin.