Abstract

Erigbali P.P.*, Kemelayefa OJ., Joffa PPK., Kiridi E.G., Pughikumo D.T & Potts-Johnson G

ABSTRACT

This is a preliminary phase of a research series aimed at appraising acute toxicity of five (5) analogues (designated A1 to A5) of dibenzylidene administered orally to male and female mice selected randomly; in lieu of proffering alternative medications with improved efficacy and minimal or nil deleterious side effects, particularly for pain management. The lethal dose (LD50) was estimated using Lorke's method, and acute toxicity dose appraised at 4415.88mg/kg and 5000mg/kg for 24 hours. Behavioral and physiological toxicity effects were then examined. Results showed that A3 caused mortality in a mouse (male) with the highest dosage (5000mg/kg). The mice weighed 23.93kg, and the LD50 was calculated as 4415.88mg/kg. The other 4 analogues did not cause mortality. Meanwhile, LD50 for all five (5) derivatives was higher than 3800mg/kg, which is considerable as safe dose. In conclusion, A1, A2, A4 and A5 administered orally were relatively non toxic in both male and female mice while A3 was toxic in a male mouse. Whether LD50 observed is associated with sex seem positive in this preliminary study.