International Journal Of Modern
Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Science & Pharmacy Professional

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2319-5878
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Abstract

MULTICOMPONENT ONE-POT SYNTHESIS OF 1,4-DIHYDROPYRANO [2,3-C] PYRAZOLE DERIVATIVES EMPLOYED CAMPHOR SULFONIC ACID AND BIOEVLUATION

Y. Avinash Kalyan and Dr. N. Krishnarao*

ABSTRACT

In the present work, a simple and an efficient protocol is developed for thesynthesis of derivatives of dihydropyrano [2,3-c] pyrazole. These derivatives can beobtained by a one pot, multi component reactions of substituted aromatic aldehydes,ethylacetoacetate, hydrazine hydrate, malanonitrile in the presence of a catalyticamount of camphorsulfonicacid in ethanol medium. The structure of the derivativesevaluated by spectroscopic methods viz; 1HNMR, 13CNMR and LCMS and alsostructure of the compound was determined by elemental analysis. This methodprovides number of advantages such as high yield, shorter time of reaction, mildreaction condition, operational simplicity, easy work-up procedure withenvironment friendly nature. The purification of desired products has beendeveloped by non-chromatographic methods. The antimicrobial activity wasevaluated by these derivatives.

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