International Journal Of Modern
Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Science & Pharmacy Professional

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2319-5878
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Abstract

AN EFFICIENT SOLVENT FREE ONE-POT SYNTHESIS OF 2-PHENYL-1HBENZIMIDAZOLE DERIVATIVES BY ORGAN CATALYST AND EXPLORING ANTIMICROBIAL ACTIVITY

M. Anjaneyulu, D. V. L. Sirisha and Dr. N. Krishnarao*

ABSTRACT

As a part of our research programed, in present study of the developed method forthe synthesis of some novel analogous of 2-phenyl-1H-benzimidazole employingBronsted acid catalyst that contain the basic skeleton in numerous bioactivederivatives. The newly prepared compounds were synthesized from thecondensation of reaction between O-Phenylenediamine and various substituted arylaldehyde in the presence of trifluoro acetic acid in aqueous medium. The yield ofall newly derivatives synthesized compounds was found to be in the range of 85-95%. The synthesized compounds were evaluated by using 1HNMR, 13CNMR andMASS spectral data together with elemental analysis. In addition to examined thebiological activity.

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