ONE POT SYNTHESIS OF SERIES OF 7, 7-DIMETHYL-4-PHENYL -TETRAHYDRO QUINAZALONES-(1H, 3H) - 2, 5-DIONES EMPLOYING BRONSTD ACID AND BIOEVLUATION
Seera Durga Prasad and Dr. N. Krishnarao*
ABSTRACT
The present investigation, an efficient and cost-effective method for the synthesis of derivatives of 7,7-dimethyl-4-phenyl tetrahydroquinazaloine- (1H,3H)-2,5-diones promoted by Methanesulphonic acid dimedone, urea and substituted aromatic aldehydes employing camphorsulfonic acid as acatalyst under solvent free condition. The chemical structures of the titled compounds were confirmed by 1H-NMR & 13CNMR, Mass spectral and Elemental analysis. Antimicrobial activities of the titled compounds were also examined by vaious strains and exhibited mild to moderate anti-bacterial and anti-fungal activities.
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