MULTI COMPONENT SYNTHESIS AND CHARACTERIZATION OF DERIVATIVES OF 2-AMINO-7, 7-DIMETHYL-5-OXO-4-PHENYL-5, 6, 7,8-TETRAHYDRO-4H-CHROMENE-3-CARBONITRILE AND ANTI- MICROBIAL ACTIVITY
Kudrapu Leelamanikant and Dr. N. Krishnarao*
ABSTRACT
In present investigate the synthesis of 2-amino-7, 7-dimethyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile can be obtained the reaction of substituted aromatic aldehydes (1.2mmol), dimedone (1mol),malonitrile(1mol), in the presence of Methanesulphonic acid in ethanol as solvent at 750C condition. All the compounds were examined by advanced spectroscopic data (1HNMR, 13C NMR& LCMS) and the structural determination was calculated by elemental analysis. In addition to the all newly synthesized compounds were screened by their microbial activity.
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