International Journal Of Modern
Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Science & Pharmacy Professional

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2319-5878
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Abstract

THE STUDY ON UROLITHIATIC ACTIVITY OF CISSUS QUADRANGULARIS PLANT IN EXPERIMENTAL ANIMAL MODEL

MD Faheemuddin*, Mohammed Arshad, P. Sai Priya, Putta Pravalika, Shruthi Verma, G. Shravani and Suryam Gugulothu

ABSTRACT

The present study was undertaken to evaluate the Urolithiatic Activity of the medicinal plant Cissus quadrangularis. The study was carried out for 14 days in which the aqueous extract of Cissus quadrangularis was used at a dose at which it is used to cure bone fracture treatment in ayurvedic practices 7. Four groups consisting of three Wister rats in each group weighing 120 to 150 grams were taken. Normal group (normal water), control group (Ethylene Glycol (EG) induced urolithiasis) Test group-I (500mg/kg) Test groupII (750mg/kg) after 14 days the animals weight analysis, urine analysis, blood analysis and histopathological studies were carried out. The results shown the significant development of calcium oxalate crystals in control, TestI & Test-II groups. From the study it is concluded that the dose used for the bone fracture treatment leads to urolithiasis, so the dose adjustment is required. Further study is required to prove exact mechanism of calcium oxalate crystals.

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