Abstract

Dharmendra Kumar Mishra, Kalpana Badoniya, Surendra K. Jain, Krishan Kishore Badoniya*

ABSTRACT

The complexity of the eye structure and its physiology turned ocular drug administration into one of the most challenging topics in the pharmaceutical field. Conjunctivitis is one of the most common ophthalmic disorders. Topical administration of drugs leads difficulty in overcoming the eye barriers, which are both physical and chemical, reduces drug bioavailability, and the frequency of administration must be increased to reach the therapeutic effect. Lipid nanoparticles seem to be a great alternative to ocular drug delivery. In this work we developed solid lipid nanoparticles of Miconazole for the effective treatment of conjunctivitis. Drug exicipient compatibility study was done. SLNs were prepared using hot homogenization followed by probe sonication techniques. The Box-Behnken design was employed for Miconazole hydrochloride loaded nanoparticles. The particle size and entrapment efficiency showed a wide variation of 254-699 nm and 80.5 -87.8% respectively. The optimum formulation exhibited a zeta potential of 23 mV, entrapment efficiency of 84%, Miconazole release of 8% after 1 h, and time to release of 50% of the drug of 5 h. It produced a 1.5-fold and 3-fold increase in the cumulative amount permeated and cumulative percentage permeated, respectively, compared with other tested formulations.