Abstract

Snehalatha*, Vineetha K. and Krishnanandha Kamath K.

ABSTRACT

Novel drug delivery system can significantly improve the performance of bioactive in terms of patient compliance, safety, efficacy and novelty. Aspasomes is a novel carrier for drug delivery; it is an Ascorbyl palmitate vesicle with their own biological activity. Ascorbyl palmitate is explored as bilayer vesicle forming material for Aspasomes. Ascorbyl palmitate forms vesicles in combination with cholesterol and a negatively charged lipid (dicetyl phosphate). Aspasomes are capable to suppress pigmentation of the skin and decomposition of melanin; it also improves elasticity of the skin by promoting the formation of collagen. Ascorbyl palmitate is more stable than ascorbic acid and its lipophilic character is beneficial for its skin penetration. Aspasomes are prepared by film hydration method. The potential of Aspasomes vesicles to overcome biological barriers, enhance drug bioavailability, and minimize systemic side effects is underscored, along with recent advances and future prospects in this rapidly evolving field. This review article provides a thorough examination of the design principles, formulation strategies, classifications, mechanism of action, evaluation parameters and therapeutic applications of aspasomes vesicular drug delivery systems.