DEVELOPMENT AND COMPARISON OF CEFIXIME NANO EMULSIONS WITH SOME OF THE CEFIXIME FORMULATIONS AVAILABLE IN INDIAN MARKET
Lakavath Sunil Kumar*, Parna Akshaya, Kariyappagari Lakshmi, Dudekula Madarvali, P. S. Bhavya and Lokireddy Satya Narayana Reddy
ABSTRACT
The primary intention of this research was to progress and assess a Nano emulsion (NE) formulation of cefixime with the goal of enhancing its oral bioavailability. The formulation of the cefixime NE utilized a compilation of homogenization and sonication methods. Through comprehensive FTIR studies, the affinity of the drug and its excipients was confirmed. Characterization of the augmented Cefixime NE elaborate a sequence of analyses counting Particle size (PS) determination, assessment via Differential Scanning Calorimetry (DSC), evaluation of Zeta Potential (ZP), drug content measurement, and in-vitro drug release studies. To assess its antimicrobial activity, the cefixime Nano emulsion was subjected to testing using the Disc plate proceeding counter to Escherichia coli (E. coli) strains, with varying concentrations of the created groundwork, tested on nutrient agar. The Minimum Inhibitory Concentration (MIC) was determined liable the calculation of Zone of inhibition.
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