THE SYNTHESIS A SERIES OF 2 – ANILINOPHENYLACETIC ACID DERIVATIVS FOR THEIR ANTI-INFLAMMATORY ACTIVITY
*Dr. Narendra Singh, Dr. Govindasamy Jeyabalan, Dr. Yogendra Singh and Papan Garai
ABSTRACT
The synthesis of a series of 2-anilinophenylacetic acids, close analogue of diclofenac, is synthesized and tested for their anti-inflammatory activity by Carrageenin Induced Paw edema method. Each 2-anilinophenylacetic acid derivative will be screened for their anti-inflammatory activity. It was also found that the synthesized compound YS-1,YS-4, YS-5, and YS-6 has shown significant anti-inflammatory activity whereas all the other compound have showed mild to moderate anti-inflammatory activity as compared to standard drug. Syntheses have been carried out following simple methodology in excellent isolated yields. The structure and purity of the original compounds were confirmed by melting point, IR, TLC, and elemental analysis. These preliminary results indicate that some of compounds are exhibiting good activity.
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