Abstract

*Dr. Narendra Singh, Dr. Govindasamy Jeyabalan, Dr. Yogendra Singh and Gaurav Sharma

ABSTRACT

The main of the study was to synthesize a series of 1, 4-dihydropyridine derivatives and tested for their anticonvulsants activity. All the synthesized novel compounds were screened for anticonvulsants activity. The anticonvulsant activities of these compounds were evaluated by using the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ) seizure models in mice. It was also found that P-03 compound was more potent as compared to other synthesized compounds with anticonvulsants activity. Whereas all the other compound have showed mild to moderate anticonvulsants activity as compared to standard drug. Syntheses have been carried out following simple methodology in excellent isolated yields. The structure and purity of the original compounds were confirmed or identified by melting point, TLC, IR spectra analysis and elemental analysis. These preliminary results indicate that some of compounds are exhibiting good anticonvulsants activity.