Abstract

Aniket Sahu, Harshita Jain*, Arpit Shrivastava and Vaihsali Yadav

ABSTRACT

The Andrographis paniculata have been used in traditional folklore for variousinflammatory and analgesic uses amongst other uses. In present study we evaluatedthe analgesic and anti-inflammatory activity of the leaf extract of Andrographispaniculata. The extraction of leaves powder was done in three different solventaqueous, methanol and ethanol. All three extract did not show any acute toxicity.Analgesic effects were tested in mice using hot plate and writhing tests. The resultsshowed that, at 100 mg/kg, all tested substances have significant analgesic effects,and the highest potency was seen with 200 and 300 mg/kg. Anti-inflammatoryactivity were tested by carrageenan induced paw edema in rats. Methanol extract(200 and 400 mg/kg) showed a significant (p<0.001) reduction in paw volume in adose dependent manner at 3rd and 5th h. The inhibitory effect of the Methanolextract at (400 mg/kg) was found to be 40.92% at 3rd h and 51.47% at 5th. However,aqueous extract (400 mg/kg) showed significant (p<0.001) inhibition in pawvolume at 5th h with 22.76% inhibition when compared to carrageenan controlgroup. These could be further developed as analgesic, antipyretic and antiinflammatoryagents, without any serious toxicity.