Abstract

Arya Arun, Anfi D. P., Shaiju S. Dharan and Sam Jeeva Kumar*

ABSTRACT

This review is mainly focused on updating knowledge aboutcholestatic associated pruritis and understanding basic mechanism with therapeutic management. It summarizes the characteristics of clinical epidemiological studies, diagnostic approach and evidence based therapeutic recommendations regarding the form of pruritis. Cholestasis is defined as a decreasing bile flow due to impaired secretion by hepatocytes or obstruction of bile flow through intra or extra hepatic bile ducts. Therefore, the clinical definition of cholestasis in any condition in which substances normally excreted in to bile are retained. Pruritis is frequent symptom that accompanies several liver diseases, particularly cholestatic ones. It is extremely important to know about cholestatic pruritis to be sought by the patient when they experience the symptom. In addition to allowing an adequate diagnosis, a better pathophysiological; understanding of hepatic pruritis provides the identification of new therapeutic targets and optimization of approaching patients with this condition.