Abstract

Kethandapatti Srinivasa Sainath*, Lakavath Sunil Kumar*, Dr. Eranti Bhargav and Haranath Chinthaginjala

ABSTRACT

Objective: The existing study is concerned with the design and assessment ofDXM microspheres (MS) via ionic gelation. Methodology: The microspheres areprimed by using the ionic gelation method. All the ingredients were individuallyweighed and the calcium chloride solution was disseminated in the drug containingan aqueous solution of sodium alginate. The resultant solution has to be added dropwisewith the help of a syringe to the Cacl2 solution. So the microspheres areformed by the isotropic relation between the calcium chloride and sodium alginatewhich formed the microspheres by the spherical rigid-walled calcium alginatemicrospheres. Results: The parameters of flow properties studies revealed that theset microspheres have good flow properties. They are within the limits. The particlesize of DXM microspheres was found to be 42.83μm which is within the limits.The PSA was done by using the optical microscope method. Conclusion: Theresults revealed that with this method we can ensure good establishment ofmicrospheres to allow the drug into the systemic circulation.