International Journal Of Modern
Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Science & Pharmacy Professional

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2319-5878
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Abstract

EVALUATION OF ANTIDIABETIC ACTIVITY OF ETHANOLIC EXTRACT OF PASSIFLORA EDULIS IN ALLOXAN INDUCED DIABETIC RATS

Sajja Ravindra Babu*, G. Soumya, K. Preeti, D. Chandana and K. Anil

ABSTRACT

The present study was carried out to evaluate the antidiabetic activity of ethanolic extract of whole plant of Passiflora edulis in alloxan induced diabetic rat model in which the rats were treated with alloxan (150mg/kg, i.p). The study was carried out on a 17 day protocol and the parameter monitored was blood glucose levels. Our study clearly indicated that the ethanolic exract of Passiflora edulis whole plant showed significant antidiabetic activity at both doses (250mg/kg and 500mg/kg) as significant decrease (P<0.05) in blood glucose was observed. The ethanolic exract of Passiflora edulis whole plant also showed significant increase (P<0.05) in body weight when compared with diabetic control rats. The results indicated that the extract of Passiflora edulis at high dose (500mg/kg) exhibited significant (P<0.05) anti-hyperglycemic activity than low dose of (250mg/kg) of extract in diabetic rats. The present study indicated that EEPE possessed the highest phenolic and flavonoid compounds and exhibited strong antidiabetic and antioxidant activities.

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