Abstract

Dr. C. Aparna*, Suguna Aishwarya Kuppa, Gajulapalli Tulasi, Gathpa Harshitha Reddy, Naviya Putti and Gorentla Nagamani

ABSTRACT

Dissolution testing plays an important role as a routine quality control test, for characterizing the quality of the product and plays a major role in drug development as it determines bioavailability and therapeutic efficacy. Dissolution of salicylic acid was carried out using various apparatus like the rotating basket, the rotating paddle, the rotating basket with paddle, the stationary basket-rotating paddle, and flow through cell system. The objective of this study was to study the suitability of apparatus for dissolution studies of salicylic acid. Salicylic acid compacts and capsules were prepared and dissolution studies were performed using USP type I and type II apparatus. The difference and similarity factors were calculated to compare the dissolution profiles of paddle and basket methods for both these dosage forms. The f1 & f2 values complied with the acceptance criteria, and no notable change was observed. Hence, the two apparatus may be interchangeable for carrying out the dissolution of salicylic acid.