Abstract

Harsh Jain*, Dr. Prateek K. Jain, Arpit Shrivastava, Sameeksha Jain, Prakhar Nema and Dr. Harshita Jain

ABSTRACT

Peptic ulcer disease (PUD) is a common gastrointestinal disorder characterized by lesions in the stomach or duodenal lining, often associated with Helicobacter pylori infection and the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Conventional treatment strategies focus on reducing gastric acid secretion and eradicating H. pylori using a combination of proton pump inhibitors (PPIs), H2 receptor antagonists, antibiotics, and cytoprotective agents. While these therapies are generally effective, they are not without limitations, including drug resistance, side effects, recurrence, and high costs. In recent years, there has been growing interest in herbal medicine as a complementary or alternative approach to managing PUD. Various herbal remedies, such as Glycyrrhiza glabra (licorice), Curcuma longa (turmeric), and Aloe vera, have shown promise in both preclinical and clinical studies for their anti-inflammatory, anti-ulcerogenic, and mucosal protective properties. This review provides a comprehensive analysis of conventional therapies and explores the potential of herbal treatment options for PUD. We discuss the pharmacological mechanisms, efficacy, and safety profiles of both approaches, and consider the potential benefits of integrative strategies that combine conventional and herbal therapies. The review aims to provide healthcare professionals with an updated understanding of PUD management and to highlight the need for further research into safe and effective treatment modalities.