Abstract

Arbaz Khan* and Surendra Kumar Jain

ABSTRACT

Plants have been one of the important sources of medicines since the beginning of human civilization. There is a growing demand for plant-based medicines, health products, pharmaceuticals, food supplements, cosmetics etc. According to World Health Organization, approximately 85% population of the developing countries are facing difficulties to afford synthetic drugs and are relying on traditional medicines mainly of plant origin in order to maintain their primary health care needs. Plants are being used in various disorders. The aim of the study was to evaluate the antipyretic activity of methanolicflower extract of Polemonium reptans using Brewer’s yeast-induced pyrexia model in Wister strain albino rats. The methanolicflower extract at a dose of 100mg/kg &200 mg/kg were evaluated forantipyretic activity. The extract of Polemonium reptans plant showed a significant (P<0.05) dose dependentantipyretic effect in yeast induced elevation of rectal temperature in experimental rats when compared with the standardparacetamol. So it can be recommended for further studies. Phytochemical analysis revealed the presence of glycosides, carbohydrates, saponins, alkaloids. The total phenolic content of methanolicflower extract of Polemonium reptans was found to be 56mg/100mg followed by flavonoids content was found to be 16.66mg/100mg respectively. The activities of methanolic flowers extract against DPPH assay method were concentration dependent with IC50 values of ascorbic acid and extracts 21.77 and 48.85μg/ml respectively. These data therefore suggest that extract of Polemonium reptans possesses significant antipyretic activity and it mechanism could be by inhibition of release inflammatory mediators and prostaglandins.