Abstract

Jay Vishwakarma*, Prince Kumar Gandhi, Rahul Kumar Yadav, Prajjwal Tiwari, Pushkar Sharma, Puneet Kumar Yadav, Raja Kumar and Jagdish Chandra Rathi

ABSTRACT

The solubility of a drug has a significant impact on its formulation and bioavailability. The poor aqueous soluble drugs often have limited effectiveness due to this. The conventional solubilization techniques, though effective, often require expensive or toxic reagents. Hydrotropic solubilization is a safer alternative, that enhances the aqueous solubility through non-toxic and easily available hydrotropic agents. Mixed hydrotropic solubilization is advanced extension of hydrotropic solubilization, which includes use of multiple hydrotropic agents instead of single hydrotropic agent in order to increase aqueous solubility of drug. This research study evaluates the efficiency of mixed hydrotropic method for ibuprofen, a poorly water-soluble drug using a blend of urea and sodium citrate as the hydrotropic agents in mixed blend. The results demonstrated that lower volume of solvent is needed with mixed hydrotropic than with hydrotropic method to dissolve ibuprofen. In addition of being eco-friendly and reducing the need for high concentrations of individual hydrotropic agent, mixed hydrotropic method also reduces the toxicity risk. Mixed hydrotropic solubilization offers a highly efficient and cost-effective method for improving the solubility of drugs that are poorly soluble in water.