International Journal Of Modern
Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Science & Pharmacy Professional

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2319-5878
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Abstract

LEWIS ACID CATALYSED - MULTICOMPONENT SYNTHESIS OF 1H-PYRIDO[2, 1- B]QUINAZOLIN-11-ONE AND BIOEVLUATION

Dr. DVL. Sirisha, V. Sureshgowd, Dr. V. Narasingrao, B. V. Durgarao, Dr. N. Krishnarao and Dr. Shaik Lakshman*

ABSTRACT

This method is very suitable and an efficient procedure for preparation of 1H-Pyrido[2, 1-b] quinazolin-11-onederivative can be synthesized by promoted aLewis acidcatalyst which is designed. The preparation of 1H-Pyrido[2,1-b]quinazolin-11-one derivatives fromIsatin, 2-bromopyridine with KHCO3 subjectedbyZrOCl2 in CH3CNas solvent and the desired compounds were characterized by advanced spectral techniques IR, 1NMR, 13NMR and LCMS. This method is also rate of reaction as well as yield enhancement of desired compound. In addition to study of antimicrobial activity of the titled derivatives.

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