MEROZOITE SURFACE PROTEIN - 1 POLYMORPHISM IN MALARIA INFECTED PATIENTS ATTENDING FEDERAL MEDICAL CENTRE, YENAGOA BAYELSA STATE
Pughikumo D.T.*, Alade T.O., Pughikumo O.C. and Oruye E.R.
ABSTRACT
Malaria is a major public health issue in Nigeria and the genetic structure of malariaparasite may affect its transmission model and control strategies. Merozoite surfaceprotein (MSP – 1) is a vitral protein found on the surface of the merozoites andplays a crucial role in the invasion of new erythrocytes. This study was aimed atdetermining the polymorphism of Plasmodium falciparum MSP-1 gene in malariainfected patients who visited a federal medical centre. A total of 50 blood sampleswere collected and analyzed using standard parasitological and genotypictechniques. Out of the samples obtained for this study, 3 (6%), and 13 (26%) werepositive in RDT and PCR in that order. All the 13 PCR positive samples were alsopositive for MSP-1-K gene whereas none was positive for MSP-1-M, and MSP-1-Rgenes. It may be inferred from this that MSP 1-K appears the most prevalent of theallele of plasmodium falciparum MSP-1 in the study population.
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