Abstract

Maria Thottiyil Babu*, Shahrukh Mohammed

ABSTRACT

Drug-induced malabsorption occurs when medications impair nutrient absorption by inhibiting enzymes, damaging mucosal tissue, or altering gut microbiota. Medications such neomycin, cholestyramine, antacids, and methotrexate may induce deficits in vitamins A, D, E, K, B12, calcium, and iron, thereby exacerbating nutritional condition. The processes encompass enzyme inhibition, direct mucosal injury, compound formation, and modified gut motility. Clinical symptoms vary from persistent diarrhoea to subclinical deficits. Management techniques encompass the identification of causal medications, modification of therapy, and supplementation of lacking nutrients. Research underscores the significance of vitamin A in mitigating methotrexate-induced malabsorption. Healthcare professionals should oversee vulnerable persons and execute early interventions via food adjustments and medication evaluations. Future investigations should examine specific therapeutics to reduce drug-induced intestinal damage while maintaining therapeutic efficacy.