Abstract

Avani T. C.*, Deekshitha and A. R. Shabaraya

ABSTRACT

Nanoemulgels are advanced topical drug delivery systems that enhance drug penetration, stability, and therapeutic efficacy by combining the benefits of nanoemulsions and gels. They effectively overcome the skin’s stratum corneum barrier, improving the solubility, permeability, and bioavailability of hydrophobic drugs. These formulations are composed of oils, surfactants, co-surfactants, penetration enhancers, gelling agents, and stabilizers, ensuring optimal drug delivery. Nanoemulgels are prepared using high-energy techniques such as ultrasonication and microfluidization, as well as low-energy methods like spontaneous emulsification and phase inversion. They are widely used for treating various skin conditions, including infections, psoriasis, alopecia, acne, and melanoma, offering enhanced absorption, prolonged drug release, and reduced systemic side effects. Their non-greasy nature, easy application, and ability to bypass first-pass metabolism contribute to improved therapeutic outcomes. Comprehensive evaluation parameters, such as pH, viscosity, spreadability, drug content, in-vitro drug release, and stability studies, ensure their effectiveness and reliability in dermatological applications.