Abstract

Inchara K. O.*, Deekshitha and A. R. Shabaraya

ABSTRACT

Niosomes, non-ionic surfactant-based vesicles, have emerged as a promising drug delivery system for both hydrophilic and lipophilic drugs. This study focuses on the formulation and evaluation of a niosomal gel intended for topical application, offering advantages such as enhanced drug penetration, prolonged release, improved stability, and reduced systemic side effects. Niosomes are structurally similar to liposomes but are more chemically stable and cost-effective due to the use of non-ionic surfactants. Various methods such as ether injection, sonication, thin-film hydration, and reverse phase evaporation are employed for niosome preparation. The prepared niosomes were incorporated into gel bases to enhance patient compliance and ensure localized delivery. Evaluation parameters included entrapment efficiency, vesicle size, in-vitro drug release, and structural integrity. The study concludes that niosomal gels are a potent topical delivery system capable of improving therapeutic efficacy while minimizing unwanted effects. Further research could help in optimizing formulation techniques for better clinical outcomes.