FORMULATION AND ASSESSMENT OF CIMETIDINE LOADED SOLID LIPID NANOPARTICLES FOR ENHANCING ORAL BIOAVAILABILITY
Dr. Jagpal Singh*, Akansha Nirwal, Deepak Kumar, Sagar Kumar and Dr. Girendra Kumar Gautam
ABSTRACT
Oral drug delivery is the most common and preferred route of administration due to its ease of administration and patient compliance. However, low bioavailability remains a significant challenge for certain drugs, including Cimetidine, due to factors such as poor aqueous solubility, low stability, and extensive first-pass metabolism. Solid lipid nanoparticles (SLNs) have emerged as a promising approach to enhance the oral bioavailability of poorly water-soluble drugs. In this study, we aimed to prepare and evaluate Cimetidine- loaded SLNs to improve its oral bioavailability. The Cimetidine-loaded SLNs were prepared using a solvent emulsification-evaporation technique and characterized for their physicochemical properties, drug loading efficiency, in vitro release profile, and pharmacokinetic parameters.
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