MULTI COMPONENT ONE POT SYNTHESIS OF METHYL- 6-METHYL-4-PHENYL-2-THIOXO-1, 2, 3, 4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE DERIVATIVES PROMOTED BY IODINE AS CATALYST
B. Siddesu, Y. Mohan Rao, E. Naga Raju and K. Jagannadham*
ABSTRACT
The present study deals with the exploration of chemistry and medicinal diversity of pyrimidine-2-thiones. An efficient three component one pot synthesis of Methyl-6-methyl-4-phenyl -2-thioxo-1, 2, 3, 4-tetrahydro pyrimidineidin-5-yl)ethanone based on the reaction of readily available aromatic aldehyde, acetyl acetone and thiourea in the ethanol as a solvent followed by I2 as a catalysed dehydration. The products were obtained in moderate to good yield under mild, solvent as well as catalysed conditions. The structure of these compounds has been evaluated on the basis of their advanced spectroscopic data 1HNMR, 13CNMR and LCMS spectral data and also structural determination was estimated by elemental analysis. In addition to examined antimicrobial activities.
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