Abstract

Rajkumari Kushwaha *, Rohit Kurmi, Rahul Kumar Sisodiya, Rashmi Patel and Saumya Malaiya

ABSTRACT

We predict that global demographic shifts will make neurodegenerative diseases(NDs) a major concern for public health and medicine in the coming years.Degeneration or loss of neurons, which is mostly responsible for severe mentaldisease, is the primary manifestation of NDs. This degradation of neurons results innumerous neuropsychiatric issues and a person's long term impairment. As t hepopulation ages, the prevalence of conditions such as Alzheimer's and Parkinson's isexpected to rise significantly, placing increased pressure on healthcare systems.This urgent need for effective treatments and preventative measures will driveresearc h and innovation in neurology and geriatric care. Additionally, the bloodbrain barrier (BBB), a tight junction of the brain, has a protectiv e function as abiological barrier that can keep toxins, medications, and other foreign substancesout of the brain. But it's hard to get drugs to the brain in NDs (like MS, Alzheimer's,Parkinson's, etc.). The majority of the approved treatments for NDs o nly help withthe symptoms that are linked to the condition. The BBB and drug associated sideeffects are two reasons why the current treatments have not been able to stop theprogression of NDs. The pathogenesis of NDs is incredibly complex, withnumerous pathogenic processes. involved in the onset and progression; as a result,patients with ND have shown a restricted survival rate. Therefore, comprehendingthe precise process underlying NDs is essential to creating other strategies forraising the surviva l rates of ND patients. The current analysis clarifies the variouscellular mechanisms behind NDs and innovative therapeutic approaches togetherwith their clinical significance, which will help researchers come up with differentways to overcome the drawb acks of traditional ND treatments. The present projectprovides the potential to enhance NDs' treatment approach in the near future.