DESIGNED A SYNTHESIS OF SCHIFF BASE CONTAINING ETHYL 2- AMINO BENZOATE MOIETY PROMOTED BY BRONSTED ACID
Y. Srilaxmi, K. D. Prabodh, B. Iswarya Lakshmi and Dr. N. Krishnarao*
ABSTRACT
The present study, to investigate the synthesis of bioactivity of an development method for the synthesis for series of Schiff bases from ethyl 2-aminobenzoate with substituted aromatic aldehydes using P-Toluene sulphonic acid in ethanol solvent at reflux. The intermediate moiety ethyl 2-aminobenzoate can be synthesized from 2-aminobenaoic acid and ethanol small amount of concentrated phosphoric acid which is obtained from pthalic anhydride with sodium hypo bromide. All the newly synthesized derivatives were evaluated by the advanced spectroscopic data (1H-NMR, 13C-NMR and LCMS) and also structural determination were calculated by elemental analysis. Besides to all compounds were screened by their biological activities.
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