International Journal Of Modern
Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Science & Pharmacy Professional

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2319-5878
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Abstract

AN EFFICIENT ONE-POT SYNTHESIS OF 7, 7-DIMETHYL-4-PHENYL-2-THIOXO-2, 3, 4, 6, 7, 8- HEXAHYDRO-1H-QUINAZOLIN-5-ONES PROMOTED BRONSTED ACID

B. Sai, B. Divya, K. Neelakantam and K. Jagannadham*

ABSTRACT

A straight forward one pot three component synthesis of seven novel derivatives 7, 7-dimethyl-4-phenyl-2-thioxo-2,3,4,6,7,8-hexahydro-1H-quinazolin-5-one by a cyclocondensation of dimedone and substitutes aromatic aldehyde with thiourea in the presence of Bronsted acid trichloroacetic acid (TCSA) as a catalyst with to excellent yields. All structures of the desired compounds were evaluated by 1H NMR and 13C NMR spectroscopy. The antibacterial activity of some synthesized compounds was investigated against bacterial strains and fungal strains. Some of these compounds exhibited a good to significant antibacterial activity.

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