Abstract

Sowjanya Kondru*, Srinivasarao Varagani, Kavya Vadduru, Sai Pravallika Gadupudi and Dharani Munnangi

ABSTRACT

Background: Stevens-Johnson syndrome SJS is a very rare but serious and potentially life-threatening mucocutaneous reaction, and is usually drug-induced. It manifests as widespread skin detachment, erosions of mucosa, and systemic symptoms. Some of the drugs most commonly involved are antibiotics, especially beta-lactams. Case Presentation: This is a case of a 56-year-old female patient suffering from Stevens-Johnson syndrome after usage of amoxicillin-clavulanic acid for respiratory tract infection. The patient presented with very high fever and painful erythematous skin lesions that blistered with mucosal involvement of the oral and ocular surfaces, accompanied by Nikolsky's sign positive. The antibiotic was immediately stopped and the patient treated with IV corticosteroids, supportive care wound treatment and mucosal protection, to an improvement achieved with none suffered long-term consequences. Conclusion: This case emphasizes the importance of early detection and urgent removal of the offending drug when managing SJS. The case also stresses the need for alertness concerning severe ADRs with even the commonly used drugs and timely supportive multidisciplinary care, which is vital for recovery and preventing complications.