ONE POT SYNTHESIS OF 5 AMINO 3 PHENYLISOXAZOLE 4 CARBONITRILE DERIVATIVES EMPLOYED BY TIO 2 AS A CATALYST
B. Laxmana Rao, K. Murali, P. Bhumika and K. Jagannadham
ABSTRACT
A straigh tforward new path way and biological approach of a novel series and followed by conventional process a series of 5 amino 3 phenylisoxazole 4 carbonitrile analogous. These derivatives would obtained by aromatic aldehyde,malononitrile and hydroxylamine hydr ochloride in presence of Lews acid catalystTiO 2 in acetonitrile as a solvent at reflux. All the desired analogous were evaluatedthe advanced spectroscopic analysis such as 1 HNMR, 13 CNMR and LCMS andstructural determination of titled analogous were dete rmined by elemental analysis.In addition to the obtained synthesized derivatives were examined by their antimicrobial activity.
[Full Text Article] [Certificate Download]
