Abstract

Haranath Chinthaginjala, Lakshmi Sampada Jayanthi*, Sameer Tadipatri, Suryaprathap Thippeswamy Gari, Nishanth Goud Gadwala Vajagouni

ABSTRACT

Microspheres are the small spherical shaped particles ranging size from 1 μm to 1000 μm in diameter. They are employed in pharmaceutical industries by developing the prolonged release formulations. Microspheres have emerged as a versatile and promising platform for drug delivery, with applications spanning across various domains, including cancer therapy, vaccine development, and ophthalmic drug delivery. The unique properties of microspheres, such as their biodegradability, biocompatibility, and controlled release kinetics, make them an attractive choice for delivering a wide range of therapeutic agents, including small molecules, proteins, and peptides. In cancer therapy, microspheres have been employed for the targeted delivery of chemotherapeutic agents, resulting in improved efficacy and reduced systemic toxicity. In vaccine development, microspheres have been utilized to enhance the stability, immunogenicity, and controlled release of vaccines, thereby improving their overall effectiveness. In ophthalmic drug delivery, microspheres have been used to deliver drugs directly to the eye, providing sustained release and improved bioavailability, thereby reducing the frequency of administration. Furthermore, microspheres have also been explored for the delivery of protein and peptides, with the potential to enhance their stability, bioavailability, and controlled release. This review provides a comprehensive analysis of microspheres and their advantages and applications.