Abstract

Pooja Dave*, Anirudh Mehta, Akshay Phulgirkar, Saumil Shah

ABSTRACT

Co-amorphous drug delivery systems have recently gained considerable interest in the pharmaceutical field because of their potential to improve the oral bioavailability of poorly water-soluble drugs through drug dissolution enhancement due to the amorphous nature of the material. It is a system. It is characterized by only low molecular weight components that are mixed into a homogeneous single-phase co-amorphous blend. The use of only low molecular weight co-formers approach is desirable, as the amount of amorphous stabilizer can be significantly reduced compared with other amorphous stabilization. These formulations of solid dispersions describe their formation and mechanism of stabilization, study their impact on dissolution and in vivo performance.