SILVER NANOPARTICLES IN CANCER THERAPY: GREEN SYNTHESIS, CHARACTERIZATION, AND MECHANISMS OF ACTION
Jenanee Velayuthem V.*, Hemapriya V., Dr. Anamika P. K., Bala Vignesh K. S., Akshaya B. and Sruthika G.
ABSTRACT
The rapid advancement of nanotechnology has significantly contributed to the integration of nanoparticles in various biomedical applications. Among metallic nanoparticles, silver nanoparticles (AgNPs) are particularly noteworthy due to their distinctive physicochemical characteristics and relatively low toxicity. These nanoparticles can be synthesized through physical, chemical, or biological methods. Among these, the green synthesis approach is considered more cost-effective, sustainable, and less hazardous, owing to its environmentally friendly nature. To assess the functionality of silver nanoparticles, several characterization techniques are employed, including ultraviolet-visible (UV-Vis) spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), zeta potential analysis, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Research has demonstrated that when silver nanoparticles interact with cancer cells, they can induce oxidative stress, which may lead to mitochondrial dysfunction and ultimately cause DNA damage. This review highlights the green synthesis of silver nanoparticles using plant-based extracts and explores their potential mechanisms in cancer therapy.
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