Abstract

Tatiana V. Kornopoltseva*, Elena A. Botoeva and Julia Shurigina

ABSTRACT

A promising direction for the search and development of new adaptogenic drugs of natural origin is the study of nonspecific drugs from the arsenal of Tibetan medicine, recommended for the weakened, as well as for elderly people, as a general tonic, "giving longevity and health." Based on the prescription recipe "Glyzyrhiza-7", in the indications for use: "with pain in the kidneys, lower back, limb stiffness, sudden flushes of heat in different parts of the body" developed a dry plant extract from the roots GlyzyrrhizauralensisFisch, wood Caraganajubata (Pall.) Poir, roots Polygonatumodoratum (Mill) Druse, roots PolygonatumhumileFisch ex Maxim, bulbs OrchismasculaL., roots Rheum rhabarbarum L., roots Rubiatinctorum L. HPLC in the dry extract revealed the presence of ten marker components whose raw material source is Rheum (deoxy-raponticin, raponticin, rapontigenin, caffeic acid),Glyzyrrhiza (likuritin, glycyrrhizinic acid), Rubia (alizarin, purpurine, ruberitrinic acid, lucidin-primverozid) The dominant compounds of the licorice 7 extract are anthraquinones, the content of which was 7.65 mg/g; stelben content 6.13 mg/g; terpenes (glycyrrhizic acid) 1.67 mg/g, flavonoids and phenol carboxylic acids account for 2.07 and 1.12 mg/g, respectively. A technique has been developed for the quantitative determination of the content of glycyrrhizic acid in the dry extract (16.5%), which can be used to standardize this object.