Abstract

Shyni Bernard*, Devika N. P., Devika Viswam, Anusree R., Aslam M. S., Sonu K. A. and Bindu R.

ABSTRACT

Curcumin, the principal bioactive compound of Curcuma longa, is widely recognized for its diverse pharmacological activities, including anti-inflammatory, antioxidant, and anticancer effects. Despite its promising therapeutic profile, curcumin's poor aqueous solubility, rapid metabolism, and low systemic bioavailability hinder its clinical application. In response to these limitations, structural modification and complexation strategies have been employed to enhance its pharmaceutical potential. One such derivative, rosocyanine, a boron-curcumin complex, has emerged as a promising candidate due to its improved chemical stability and enhanced biological activity. This review presents a comprehensive exploration of the rational design, chemical synthesis, and biological screening of rosocyanine, with a focus on its relevance to pharmaceutical research and development. The synthesis pathways, reaction mechanisms, and physicochemical characterization are discussed in detail. By integrating insights from medicinal chemistry, pharmacokinetics, and pharmacodynamics, this review highlights rosocyanine as a valuable scaffold for future drug development within the pharmaceutical sciences.