HEALING PROPERTY OF FICUS EXASPERATA IN INDOMETHACIN-INDUCED GASTRIC ULCER
Ravi Chourasiya, Harshita Jain*
ABSTRACT
The Ficus Exasperata (FE) leaves extract was able to promote healing of indomethacin-induced gastric ulcers in mice. In this work we evaluated the antiulcer activity of the leaf extract of FE. The extraction of leaves powder was done in aqueous and methanol solvent. Antiulcer activity of extract was tested in albino rats. Ulceration was induced by indomethacin (30 mg/kg b.w.) through oral route. Esomeprazole was used as a reference drug with a dose of 20 mg/kg b.w., and methanolic FE extract at a dose of 200 mg/kg b.w. once daily four hours after indomethacin administration and lasted for 3 weeks. Ulcer index and % Protective index parameters were thereafter evaluated. The results showed that at 200 mg/kg dose FE showed significant antiulcer activity with ulcer index 6.63 ±0.20 and Protective index 65.88%. Gastric volume also reduced in animal group administered with FE, from 8.28 ± 0.13 to 5.26 ± 0.09. Histopathology study also performed with FE extract. Treatment with FE extract and Esomeprazole for 3 days reduced the number of inflammatory cells and mucosal congestion, and increased the number of healthy normal cells in the gastric mucosa, submucosa, serosa, and muscle layers.
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