VALORIZATION OF AGRO-INDUSTRIAL WASTE: BIOTECHNOLOGICAL POTENTIAL OF FERMENTED APPLE PEEL IN THE MODULATION OF DYSBIOSIS AND WOMEN'S HEALTH IN THE CONTEXT OF SUS
Karine Valverde Da Costa Gomes*, Cláudia Cristina Hastenreiter Da Costa Nascimento,
Gláucio Diré Feliciano
ABSTRACT
Recognized as a critical public health challenge, endometriosis transcends itsdefinition as a mere gynecological condition, manifesting as a systemicinflammatory syndrome that burdens the Unified Health System (SUS) and impairswomen's overall functionality. Emerging etiological perspectives locate thedisease's aggressiveness within the gut-uterus axis, identifying dysbiosis and"estrobolome" dysregulation, specifically bacterial β-glucuronidase hyperactivity,as mechanisms that sustain hormonal recycling and chronic inflammation. Thisintegrative review (2015–2025) investigated the biotechnological feasibility ofrepurposing apple (Malus domestica) waste into therapeutic inputs. Screeningacross PubMed, SciELO, and ScienceDirect databases revealed that agro-industrialfruit by-products act as reservoirs of pectin and ursolic acid. When subjected tosolid-state fermentation by Lactobacillus plantarum, these compounds undergobioconversion, yielding metabolites that inhibit the NF-κB inflammatory pathwayand restore the intestinal barrier. We conclude that formulating a symbiotic fromthis environmental liability aligns with Bioeconomy and One Health principles,offering the SUS a cost-effective, highly scalable prophylactic tool forcomplementary endometriosis management in Primary Care.
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