Abstract

Modupe Iretiola Builders*, Peter Uduak Ise, Sele Daniel Dem

ABSTRACT

In this study, raw egg potentiation of the anti-ulcer activity of Adonsonia digitata leaves in indomethacin induced gastric ulcer was evaluated. Thirty (30) healthy wistar rats were used, they were randomized into 6 groups of 5 rats each with free access to food and water. Group 1 animals received normal saline, ulcer was induced in groups 2,3,4,5 and 6 using indomethacin. Group 2 received no treatment while group 3,4,5 and 6 were treated with Omeprazole, 25%, 50%, and 75% of the mixture respectively. Afterwards the animals were sacrificed after 4 hours and the results from the different groups were compared. The animals in group 2 had more ulcer scores than other groups due to lack of treatment. All experimental groups administered with the mixture (Adonsonia digitata and egg) exhibited significant ulcer activities. Omeprazole a standard anti-ulcer drug also exhibited significant anti-ulcer effect similar to the group administered 50% of the mixture. In contrast to the above, the control group administered Normal saline did not show any significant activity. The raw egg and Adonsonia digitata extract mixture exhibited significant anti-ulcer activities, further study should be carried to establish the mechanism of action as well as the bioactives responsible for this activity.