Abstract

Bibi Mariyam Siddiqui*, B. K. , Deepak Basedia, Sunil Kumar Shah

ABSTRACT

The present study was aimed at the formulation and evaluation of Olsalazine-loaded nanosponges to achieve controlled and sustained drug release. Nanosponges were prepared using different polymer ratios, and the formulations were evaluated for percentage yield, entrapment efficiency, particle size, zeta potential, surface morphology, and in-vitro drug release behavior. The percentage yield of the formulations ranged from 72.25 ± 0.41% to 85.65 ± 0.55%, while entrapment efficiency varied between 70.36 ± 0.25% and 82.85 ± 0.95%. Among all formulations, F5 exhibited the highest yield and entrapment efficiency, indicating optimal formulation parameters. Particle size analysis confirmed nanoscale dimensions with uniform distribution, and zeta potential studies demonstrated good stability of the nanosponges. Scanning Electron Microscopy revealed a spherical, porous morphology of the optimized formulation. In-vitro drug release studies showed a sustained release pattern for nanosponges compared to the plain drug, with 97.65% drug release over 12 hours. Release kinetics analysis indicated that the optimized formulation followed first-order kinetics with diffusion-controlled release behavior. The results suggest that Olsalazine-loaded nanosponges are a promising drug delivery system for controlled release, potentially enhancing therapeutic efficacy and patient compliance.