ASSOCIATION OF VITAMIN D3 DEFICIENCY IN NONALCOHOLIC LIVER DISEASE
Ibtihal Hashim Azeez*
ABSTRACT
Vitamin D is an important secosteroid hormone with known effect on calcium homeostasis, but recently there is increasing recognition that vitamin D also is involved in cell proliferation and differentiation, has immunomodulatory and antiinflammatory properties. Vitamin D deficiency has been frequently reported in many causes of chronic liver disease and has been associated with the development and evolution of non-alcoholic fatty liver disease (NAFLD) and chronic hepatitis C (CHC) virus infection. The role of vitamin D in the pathogenesis of NAFLD and CHC is not completely known, but it seems that the involvement of vitamin D in the activation and regulation of both innate and adaptive immune systems and its ant proliferative effect may explain its importance in these liver diseases. Published studies provide evidence for routine screening for hypovitaminosis D in patients with liver disease. For this study, we did in methodology some tests that associated with NAFLD to identify effecting biomarker such as Liver Function tests and Lipid profile tests and Diabetes profile test. Further prospective studies demonstrating the impact of vitamin D replacement in NAFLD is required. Aim of study to identify effecting of deficiency Vit D3 for nonalcoholic liver disease.
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