Abstract

Sai Samadhan Shirsath*, Tejas Anil Kadam, Sakshi Ravindra Ingale, Rasika Dnyandeo Bhalke, Mahendra Ashok Giri

ABSTRACT

Wound care is tough. Healing takes time, infections creep in, and most standard ointments just don’t cut it—they barely sink into the skin, don’t stick around long enough, and rarely deliver enough of the drug where you want it. Calotropis gigantea has a solid reputation for fighting germs, calming inflammation, and speeding up wound repair. But so far, traditional treatments haven’t made the most of what this plant can offer. Plus, there’s not much research out there looking at how to use advanced nanocarriers to get its benefits to the skin more effectively. This study set out to make a Carbopol gel using Calotropis gigantea extract, hoping to fix some issues that older formulas had. To get the extract, we used Decoction method with distilled water. We checked things like pH, viscosity, how easy it spreads, We checked Physical Characteristics, Biocompatibility and Chemical Stability.We checked Spradability of the gel. We also looked at how well the gel fights bacteria, specifically Staphylococcus aureus and Escherichia coli. The optimized gel showed good physical and chemical properties, released about 85% of the drug over 12 hours, and delivered strong antimicrobial effects. What sets this study apart is the way it combines a traditional medicinal plant with modern nanotechnology to boost treatment results. This method looks promising for managing wounds and deserves more testing in living systems.