Abstract

Said Sani Said*, Abdullahi Muhammad Abdu and Aminu Sabo Abdullahi

ABSTRACT

Diabetes mellitus (DM) is a serious endocrine disorder either as a result of insulin resistance or insulin action. While the former is termed type I DM, the latter is referred to as type II DM. The aim of this study is to investigate the effect of methanolic stem bark extract of Kigelia africana (SBEka) on alloxan-induced diabetic rats. The extract was screened for phytochemical and antidiabetic properties. Alkaloids, Flavonoids, Anthraquinones, Saponins and Steroids were present in high amount. Tannins and Cardiac glycosides were present in moderate amount, while Volatile oils were totally absent. Diabetes was induced in rats after 18 hours of fasting intraperitoneally by alloxan (100 mg/kg). A total of 25 rats used, the rats were divided into five groups (GI-GV) of five rats each. GII-GV was induced with diabetes. GI served as normal control, GII were administered only distilled water and GIII were administered the standard anti-diabetic drug Glibenclamide „5 mg/kg?). While GIV (SBEka, 60 mg/kg), GV (SBEKa, 120mg/kg) were respectively administered. After eighteen (18) days of oral administration of the extracts, the animals were sacrificed and the serum was collected for analysis of lipid profile (Total Cholesterol „TC?, Low Density Lipoprotein-Cholesterol „LDL-C?, High Density Lipoprotein-Cholesterol „HDL-C?, Very Low Density Lipoprotein „VLDL? and Triglycerides „TG?). The extract treated group showed significant decreased (P