Abstract

Mahmoud M. Sebaiy* and Amr A. Mattar

ABSTRACT

A simple, specific, accurate and precise spectrophotometric method was settled for simultaneous determination of paracetamol and orphenadrine citrate in their pure form and in pharmaceutical formulation. Ratio Subtraction coupled with Extended Ratio Subtraction has been used in simultaneous determination of both drugs without prior separation. Ratio Subtraction coupled with Extended Ratio Subtraction method parameters were validated according to ICH guidelines in which accuracy, precision, repeatability and robustness were found in accepted limits. Advantages and disadvantages of Ratio Subtraction coupled with Extended Ratio Subtraction were discussed and statistical comparison between the proposed method and the reference method was performed.