STUDY OF PHYSICO MECHANICAL PROPERTIES OF BUCCAL PATCHES ALONG WITH THE PERMEATION OF LOADED ANTIHYPERTENSIVE DRUG
Gopa Roy Biswas*, Simran Shaw, Parna Pati, Sutapa Biswas Majee
ABSTRACT
The buccal patches of Atenolol were designed in such a way that the mucoadhesive layers was incorporated along with the circumference of the circular patch. The major ingredients selected for the matrix layer were the drug and control release polymer (either HPMC K15M or HPMC K4M) while the Mucoadhesive layer was predominantly comprised of gum karaya. The designed patches were subjected to different evaluations like thickness uniformity, average weight, folding endurance, mucoadhesion strength, swelling behavior. The physico mechanical properties of the patches found to be satisfactory and they were subjected to permeation studies. In vitro permeation study was conducted for 8hrs in phosphate buffer pH 6.8 using dialysis membrane. The cumulative drug permeated from formulation was found to be 32 - 49 % and the permeation profiles for each batch was almost linear. The permeability coefficient was found in a range of 0.041 cm/h. to 0.053 cm/hr and flux was found in a range of 1.43- 1.85 mg cm-2 hr -1.
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